Philippe Karoyan

Professor, UPMC

Campus Jussieu, Tour 23-33, 5ieme etage



  1. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLC ≥1 activation: evidence from mice and humans.Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, MoumnÈ R, Sarfati M, Karoyan P, Merle-Bèral H, Launay P, Susin SA.PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796.
  2. Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1. Asgatay S, Champion C, Marloie G, Drujon T, Senamaud-Beaufort C, Ceccaldi A, Erdmann A, Rajavelu A, Schambel P, Jeltsch A, Lequin O, Karoyan P, Arimondo PB, Guianvarc'h D. J Med Chem. 2014 Jan 23;57(2):421-34. doi: 10.1021/jm401419p. .
  3. Substituted prolines: from synthesis to structural applications, from peptides to foldamers. Mothes C, Caumes C, Guez A, Boullet H, Gendrineau T, Darses S, Delsuc N, Moumne R, Oswald B, Lequin O, Karoyan P. Molecules. 2013 Feb 19;18(2):2307-27. doi: 10.3390/molecules18022307.
  4. Matheron L, Clavier S, Diebate O, Karoyan P, Bolbach G, Guianvarc'h D, Sachon E.; Improving the selectivity of the phosphoric acid β-elimination on a biotinylated phosphopeptide., J Am Soc Mass Spectrom. 2012 Nov;23(11):1981-90. doi: 10.1007/s13361-012-0467-y. 
  5. Larregola M, Lequin O, Karoyan P, Guianvarc'h D, Lavielle S.; β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides. J Pept Sci. 2011 Sep;17(9):632-43. doi: 10.1002/psc.1382.
  6. Guitot K, Larregola M, Pradhan TK, Vasse JL, Lavielle S, Bertus P, Szymoniak J, Lequin O, Karoyan P.The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water. Chembiochem. 2011 May 2;12(7):1039-42. doi: 10.1002/cbic.201000707.
  7. Ben Hamidane H, Vorobyev A, Larregola M, Lukaszuk A, Tourwé D, Lavielle S, Karoyan P, Tsybin YO.; Radical Stability Directs Electron Capture and Transfer Dissociation of beta-Amino Acids in Peptides. Chemistry. 2010 Mar 16;16(15):4612-4622. 
  8. Mothes C, Larregola M, Quancard J, Goasdoué N, Lavielle S, Chassaing G, Lequin O, Karoyan ; P.Prolinoamino acids as tools to build bifunctionalized, stable beta-turns in water. Chembiochem. 2010 Jan 4;11(1):55-8. 
  9. Zins EL, Rondeau D, Karoyan P, Fosse C, Rochut S, Pepe C, Investigations of the fragmentation pathways of benzylpyridinium ions under ESI/MS conditions.; J Mass Spectrom. 2009 Dec;44(12):
  10. Moumne, R.; Larregola, M.; Boutadla, Y.; Lavielle, S.; Karoyan, P., Aminomethylation of chiral silyl enol ethers: access to beta(2)-homotryptophane and beta(2)-homolysine derivatives. Tetrahedron Letters 2008, 49 (32), 4704-4707.
  11. Mothes, C.; Lavielle, S.; Karoyan, P., Amino-zinc-ene-enolate cyclization: A short access to cis-3-substituted prolino-homotryptophane derivatives. Journal Of Organic Chemistry 2008, 73 (17), 6706-6710.
  12. Lukaszuk, A.; Demaegdt, H.; Szemenyei, E.; Toth, G.; Tymecka, D.; Misicka, A.; Karoyan, P.; Vanderheyden, P.; Vauquelin, G.; Tourwe, D., beta-homo-amino acid scan of angiotensin IV. Journal Of Medicinal Chemistry 2008, 51 (7), 2291-2296.
  13. Lukaszuk, A.; Demaegdt, H.; Karoyan, P.; Vanderheyden, P.; Vauquelin, G.; Tourwe, D., Novel, potent and selective angiotensin IV short analogues. Journal Of Peptide Science 2008, 14 (8), 143-144.
  14. Moumne, R.; Denise, B.; Parlier, A.; Lavielle, S.; Rudler, H.; Karoyan, P., One-pot synthesis of beta-amino acid derivatives via addition of bis(O-silyl) ketene acetals on iminium salts. Tetrahedron Letters 2007, 48 (47), 8277-8280.
  15. Moumne, R.; Denise, B.; Guitot, K.; Rudler, H.; Lavielle, S.; Karoyan, P., New scalable asymmetric aminomethylation reaction for the synthesis of beta(2)-amino acids. European Journal Of Organic Chemistry 2007, (12), 1912-1920.
  16. Jacquot, Y.; Broutin, I.; Miclet, E.; Nicaise, M.; Lequin, O.; Goasdoue, N.; Joss, C.; Karoyan, P.; Desmadril, M.; Ducruix, A.; Lavielle, S., HIP affinity Grb2-SH3 domain ligand incorporating C-beta-substituted prolines in a Sos-derived decapeptide. Bioorganic & Medicinal Chemistry 2007, 15 (3), 1439-1447.
  17. Moumne, R.; Lavielle, S.; Karoyan, P., Efficient synthesis of beta(2)-amino acid by homologation of alpha-amino acids involving the Reformatsky reaction and Mannich-type imminium electrophile. Journal Of Organic Chemistry 2006, 71 (8), 3332-3334.
  18. Sagan, S.; Quancard, J.; Lequin, O.; Karoyan, P.; Chassaing, G.; Lavielle, S., Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor. Chemistry & Biology 2005, 12 (5), 555-565.
  19. Mezzache, S.; Pepe, C.; Karoyan, P.; Fournier, F.; Tabet, J. C., Proton affinity of diastereoisomers of modified prolines using the kinetic method and density functional theory calculations: role of the cis/trans substituent on the endo/exo ring conformation. Rapid Communications In Mass Spectrometry 2005, 19 (16), 2279-2283.
MàJ 09/05/2017