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Home page > Research groups > Group 1: EQUIPE 1 : Méthodes de caractérisation et d’imagerie ultrasonore multi-echelle: modélisation et transfert > Research themes > Acoustic microscopy : Application to the investigation of elastic properties of bone at the tissue level.

Acoustic microscopy : Application to the investigation of elastic properties of bone at the tissue level.

Contacts : Amena Saïed, Pascal Laugier, Quentin Grimal.

Scanning acoustic microscopy enables to explore the micro-elastic properties of a material at a submillimetric resolution level. In the 50 MHz - 1 GHz frequency range, the technique allows the mapping of elastic properties of a heterogeneous material at a spatial resolution between 20 µm and 1 µm. The technique is well adapted to the assessment of bone that is a heterogeneous composite tissue characterized by a complex hierarchical organization. Our research aims at (i) developing methodologies of quantitative scanning acoustic microscopy; (ii) evaluating the micro-elastic properties of healthy or pathological bone tissue at different scales; and (iii) providing data to computational mechanical models of bone. The investigation of the determinant factors of the elastic properties of bone tissue is still a challenge and is therefore fundamental in this research. This, in particular, necessitates to relate acoustic measurements to bone material characteristics (ultrastructure, microstructure, composition, characteristics of collagen and HAP mineral crystals, etc.) as deduced from experiments with high-resolution modalities such as synchrotron radiation microtomography, small angle X-ray diffraction (sAXS), nanoindentation, Raman and Fourier transform infrared (FTIR) spectroscopy techniques, etc. The quantitative information derived from scanning acoustic microscopy can be used as input in computational mechanical models that are designed to predict the macroscopic biomechanical behavior of bone using the heterogeneous tissue micro-elastic characteristics obtained at the lower scale levels