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Accueil du site > Séminaires, conférences > Séminaires du LIP > Séminaires en 2014-2015 > David Maresca (Institut Langevin), invité par G. Renaud

David Maresca (Institut Langevin), invité par G. Renaud

Vendredi 7 Novembre 2014, 14h00

Orateur : David Maresca

Titre : Intravascular ultrasound imaging of microvasculature : a new tool for vulnerable atherosclerotic plaque identification.

Résumé : Atherosclerosis is a deadly affliction leading to heart attacks and sudden death. In 2008, 7.3 million people worldwide died of a heart attack according to the world health organization. As any organ, the heart requires blood and oxygen to maintain its function. This supply is ensured by blood vessels running along the heart surface called coronary arteries. Cardiologists now recognize that it is the development of atherosclerosis in the coronary arteries that causes heart attacks. To date, the early identification of patient presenting a high risk of cardiovascular accident remains a central issue in medicine.

Coronary arteries themselves are nourished by a network of microvessels that penetrate the layers of the arterial wall. This network is called the vasa vasorum, which literally means “the vessels of the vessels”. Recent findings indicate that the presence of vasa vasorum inside an atherosclerotic coronary lesion was associated with future risks of a heart attack.

Intravascular ultrasound (IVUS) is a high frequency echography technique at the tip of a catheter which allows to navigate inside coronary arteries and image the arterial wall with a great level of detail. This technique was the first to reveal the shapes and dimensions of atherosclerotic lesions nested in the coronary artery wall. Unfortunately, IVUS does not have a sufficient resolution to detect the vasa vasorum, which exhibits vessel diameters ranging from 200 microns down to a single red blood cell dimension.

I will present the development of intravascular ultrasound pulse sequences dedicated to the detection of ultrasound contrast agents (suspensions of resonant microbubbles that are small enough to penetrate the capillary bed after intravenous administration) and their capacity to detect vasa vasorum sized channels in controlled laboratory experiments.