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Accueil du site > Séminaires, conférences > Séminaires du LIP > Séminaires en 2015-2016 > Frédéric Gobeaux (LIONS, CEA/Saclay), invité par N. Taulier

Frédéric Gobeaux (LIONS, CEA/Saclay), invité par N. Taulier

Orateur : Frédéric Gobeaux (LIONS, CEA/Saclay)

Titre : Amyloid self-assembly of short, hormone-like peptides

Résumé : The formation of amyloid fibers is a phenomenon that has long been mainly associated with pathological contexts and protein denaturation. However, it has recently appeared that such a phenomenon is widespread in the living world. Indeed, during the past fifteen years more and more examples of amyloid fibers fulfilling functional roles have been discovered in organisms as various as plants, bacteria, fungi and mammals. More specifically, a recent study has demonstrated that many peptide hormones were stored inside pituitary secretory granules under the form of amyloid fibers. As the hormones have to be released under a monomeric form to activate their corresponding receptors, it strongly suggests that the association of the peptides under the form of amyloid fibers is reversible. My current research project aims at exploring the self-assembling capacities of neuro-hormones peptides and analogues thereof. Beyond the specific structural biology question, I am particularly interested in these short molecules because they might constitute appropriate models to tackle broader issues like biomimetic self-assembly and amyloid formation. The specific relationship between amino-acid sequences and supramolecular structures is in particular not yet fully understood and predictable. Additionally, the reversibility feature constitutes a crucial asset to design long-acting drug-release formulations. The study of these supramolecular assemblies requires collecting structural information at scales ranging from the angström to the micrometer ; I thus have adopted a multi-technique methodology that combines optical and electron microscopies, vibrational spectroscopies and x-ray scattering.