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Polarizing tissue morphogenesis by mechanical stress
Par Michel Labouesse (IBPS, UPMC)
Le 4 Janvier 2017 à 11h00 - Salle de séminaires 5ème étage, Tour 32-33


We are using a simple model, the nematode C. elegans, to analyze how mechanical forces influence specific cellular processes and conversely on how tissues withstand forces during morphogenesis. The C. elegans embryos extend by a four-fold factor along their anterior-posterior axis. Two main active mechanical forces power this extension: epidermis actomyosin contractility and muscle contractions, which exert mechanical forces on the outer epithelium. I will discuss how these forces can polarize the anterior-posterior extension by three factors, stress anisotropy, stiffness anisotropy, polarized trafficking.