Accueil  >  Séminaires  >  Cytoskeletal crosstalk during cell migration
Cytoskeletal crosstalk during cell migration
Par Sandrine Etienne-Manneville (Pasteur)
Le 26 Novembre 2019 à 11h00 - Salle de séminaires 5ème étage, Tour 32-33

Résumé

Cell migration requires a dramatic and coordinated reorganization of the different elements of
the cytoplasmic cytoskeleton, composed of three types of filamentous structures: actin
microfilaments, microtubules and intermediate filaments. Mesenchymal cells strongly interact
with and exert traction forces on the extracellular matrix through integrin-based focal adhesions
to move forward. The actin polymerization contributes to membrane protrusion while the acto-
myosin network forming stress fibers generate the traction forces. Microtubules have been
shown to play a key role in cell front-to-rear polarization as well as in the control of focal
adhesion dynamics and distribution and in focal adhesion associated stress fibers. Finally,
intermediate filaments are thought to contribute their mechanical properties to cell migration.
Looking at the collective directed migration of primary astrocytes in vitro, we have been
investigating how these three cytoskeletal structures influence one another to perform
coordinated tasks such as nucleokinesis, focal adhesion turnover, mechanotransduction and cell-
cell adhesions and insure the collective behavior of the cell monolayer.