Research  >  Micro-organisms biophysics

Micro-organisms biophysics

Microorganisms represent the dominant forms of life on Earth. They display a huge diversity of geometric shapes, behaviours and habitats. We are particularly interested in bacteria. Their size — on the order of microns — and their lifetime — on the order of hours — enable exploring from single cell level to heterogeneous, socially organized populations. We study these systems based on the development of dedicated microfabricated microfluidic devices, coupled with the most recent advances in genetics and video-microscopy and fluorescence imaging approaches. Our objective is to understand the mechanisms underpinning the behaviour of these systems under controlled environments, unveiling the causal relationships linking their physical and biological properties.

Phenotypic variability Biofilm microrheology Multi-species adherent communities Biofilm under flow Mutagenesis: Single-Cell, Real-Time Cell cycle Microfluidics of Epilithic Biofilms: impact of chlordecone



Mutation rates and effects in single cells - Science
L. Robert , J. Ollion , J. Robert , X. Song, , I. Matic, , M. Elez
  URL Full text PDF Bibtex doi:10.1126/science.aan0797



Single-cell analysis of growth in budding yeast and bacteria reveals a common size regulation strategy - Current Biology
I. Soifer , L. Robert , A. Amir
  URL Full text PDF Bibtex doi:10.1016/j.cub.2015.11.067


Single-Cell Analysis of Growth and Cell Division of the Anaerobe Desulfovibrio vulgaris Hildenborough - Frontiers in Microbiology
A. Fievet , A. Ducret , T. Mignot , O. Valette , L. Robert , R. Pardoux , A. Dolla , C. Aubert
  URL Full text PDF Bibtex doi:10.3389/fmicb.2015.01378


Division in Escherichia coli is triggered by a size-sensing rather than a timing mechanism - BMC Biology
L. Robert , M. Hoffmann , N. Krell , S. Aymerich , M. Doumic
  URL Full text PDF Bibtex doi:10.1186/1741-7007-12-17