Laboratoire Jean Perrin

LJP at a glance

LJP research activities consist in Physics at the interface of with Biology and Medicine. We develop new experimental approaches to probe complex biological systems at different scales, and we develop bio-inspired systems to develop new concepts or to improve our understanding of given biological mechanisms. A large part of our research aims at exploring the response of a biological system to external perturbations. Finally, the LJP includes a theoretical component closely interacting with experimenters.

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Next seminar

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26
MAR

Hierarchy and extremes in selections from pools of randomized proteins

By Clément Nizak (ESPCI)

March 26, 2019 at 11:00AM - Salle de séminaires 5ème étage, Tour 32-33

Variation and selection are the core principles of Darwinian evolution, but quantitatively relating the diversity of a population to its capacity to respond to selection is challenging. Here, we ...

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Millifluidics for biology
Millifluidic devices of molded PDMS allows to impose different channel geometries and thus to fine-tune the system hydrodynamical properties. The preparation is simple, fast and reproducible. At Jean Perrin, we use this technique to study the impact of physical parameters on the development of bacterial biofilms.
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Machining microstructures
Micromachining has become a serious alternative to soft photolithography to achieve surfaces with a controlled topography at micrometric scales. At Jean Perrin, we micro-machine micro-channel microstructures for microfluidics and surfaces decorated with pillars and spherical caps for studying mechanotransduction.
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Lightsheet fluorescence microscopy
With this microscopy technique, thin slices of the sample are illuminated perpendicularly to the direction of observation. It enables a high data thoughput and reduces the photodamage and stress induced on a living sample. At Jean Perrin, we combine lightsheet microscopy with calcium imaging to monitor the activity of tens of thousands of neurons in the zebrafish brain.
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Optical fibers for diagnostics
Transfering table-top multiphoton microscopy setups to clinical endoscopy is a challenge requiring multiple approaches. At Jean Perrin, we use proximal scanning of a multicore image-guide compatible with standard endoscopes and the distal scanning of a single microstructured fiber.
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News

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14
DEC 2018

HDR Defense Elie Wandersman
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05
DEC 2018

PhD defense of Florence Bansept
Florence Bansept has the pleasure to invite you to her PhD defense that will take place on Wednesday, the 5th ...

01
OCT 2018

The LJP at the 2018 Science Fair
This year, the Science Fair is back on Jussieu Campus and the Laboratoire Jean Perrin will join the ...

13
SEP 2018

PhD Defense of Aurélien Bour
Aurélien Bour is delighted to invite you to his PhD. defense on Thursday, september 13th 2018 at 2:30 ...

04
SEP 2018

Habilitation defense of André Estevez-Torres
André Estevez-Torres has the pleasure to invite you to the defense of his Habilitation for research ...

29
JUN 2018

Ph. D. defense of Olivier Ameline
Olivier Ameline is delighted to invite you to his Ph. D. defense on Friday, June 29th 2018 at 9:45 AM room ...

Latest publications

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⊞	Lipid unsaturation properties govern the sensitivity of membranes to photo-induced oxidative stress - Biophysical Journal
	A. Bour , S.G. Kruglik , M. Chabanon , P. Rangamani , N. Puff , S. Bonneau

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doi:10.1016/j.bpj.2019.01.033

⊞	Raman tweezers microspectroscopy of circa 100 nm extracellular vesicles - Nanoscale
	S.G. Kruglik , F. Royo , J.M. Guigner , L. Palomo , O. Seksek , P.Y. Turpin , I. Tatischeff , J.M. Falcon-Pérez

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doi:10.1039/c8nr04677h

⊞	Ribosomal protein eL42 contributes to the catalytic activity of the yeast ribosome at the elongation step of translation - Biochimie
	C. Hountondji , J.B. Créchet , M. Tanaka , M. Suzuki , J.I. Nakayama , B. Aguida , K. Bulygin , J.A.H. Cognet , G. Karpova , S. Baouz

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doi://doi.org/10.1016/j.biochi.2018.12.005

⊞	Environmentally Mediated Social Dilemmas - Trends in Ecology and Evolution
	S. Estrela , E. Libby , J. Van Cleve , F. Débarre , M. Deforet , W. R. Harcombe , J. Peña , S. P. Brown , M. E. Hochberg

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doi:https://doi.org/10.1016/j.tree.2018.10.004

⊞	Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish - Current Biology
	G. Migault , T.L. van der Plas , H. Trentesaux , T. Panier , R. Candelier , R. Proville , B. Englitz , G. Debrégeas , V. Bormuth

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doi:https://doi.org/10.1016/j.cub.2018.10.017