LJP at a glance

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  Optical fibers for diagnostics

  Transfering table-top multiphoton microscopy setups to clinical endoscopy is a challenge requiring multiple approaches. At Jean Perrin, we use proximal scanning of a multicore image-guide compatible with standard endoscopes and the distal scanning of a single microstructured fiber.

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  Machining microstructures

  Micromachining has become a serious alternative to soft photolithography to achieve surfaces with a controlled topography at micrometric scales. At Jean Perrin, we micro-machine micro-channel microstructures for microfluidics and surfaces decorated with pillars and spherical caps for studying mechanotransduction.

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  Millifluidics for biology

  Millifluidic devices of molded PDMS allows to impose different channel geometries and thus to fine-tune the system hydrodynamical properties. The preparation is simple, fast and reproducible. At Jean Perrin, we use this technique to study the impact of physical parameters on the development of bacterial biofilms.

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  Lightsheet fluorescence microscopy

  With this microscopy technique, thin slices of the sample are illuminated perpendicularly to the direction of observation. It enables a high data thoughput and reduces the photodamage and stress induced on a living sample. At Jean Perrin, we combine lightsheet microscopy with calcium imaging to monitor the activity of tens of thousands of neurons in the zebrafish brain.

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News

29
JUN 2020

A basic physical mechanism enables cell migration in absence of adhesion
Many cell types within the organism bind to their environment via specific adhesion molecules (integrins); ...

23
JUN 2020

Thesis defense - Loïc Marrec
I am pleased to invite you (virtually) to my thesis defense which will take place on Tuesday, June 23, 2020 at...

13
FEB 2020

Seminar/debate: Environmental impact of the digital world
La prochaine séance du groupe de réflexion "Faire de la recherche dans un monde fini" sera ...

15
JAN 2020

Séminaire/débat: Crise de l'entropie
La prochaine séance du groupe de réflexion "Faire de la recherche dans un monde fini" sera ...

05
DEC 2019

Habilitation defense - Volker Bormuth
Volker Bormut has the pleasure to invite you to his HdR defence entitled:‘Mechanosensitivity of ...

21
NOV 2019

Séminaire/débat: Les ressources énergétiques sont-elles finies?
Dans le cadre du groupe de réflexion "Faire de la recherche dans un monde fini", André ...

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