Laboratoire Jean Perrin

LJP at a glance

LJP research activities consist in Physics at the interface of with Biology and Medicine. We develop new experimental approaches to probe complex biological systems at different scales, and we develop bio-inspired systems to develop new concepts or to improve our understanding of given biological mechanisms. A large part of our research aims at exploring the response of a biological system to external perturbations. Finally, the LJP includes a theoretical component closely interacting with experimenters.

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The LJP is committed to support the extension of young researchers' contracts.
Reat the motion of the lab about the funding of extensions due to the covid crisis (in French).

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Lightsheet fluorescence microscopy
With this microscopy technique, thin slices of the sample are illuminated perpendicularly to the direction of observation. It enables a high data thoughput and reduces the photodamage and stress induced on a living sample. At Jean Perrin, we combine lightsheet microscopy with calcium imaging to monitor the activity of tens of thousands of neurons in the zebrafish brain.
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Optical fibers for diagnostics
Transfering table-top multiphoton microscopy setups to clinical endoscopy is a challenge requiring multiple approaches. At Jean Perrin, we use proximal scanning of a multicore image-guide compatible with standard endoscopes and the distal scanning of a single microstructured fiber.
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Millifluidics for biology
Millifluidic devices of molded PDMS allows to impose different channel geometries and thus to fine-tune the system hydrodynamical properties. The preparation is simple, fast and reproducible. At Jean Perrin, we use this technique to study the impact of physical parameters on the development of bacterial biofilms.
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Machining microstructures
Micromachining has become a serious alternative to soft photolithography to achieve surfaces with a controlled topography at micrometric scales. At Jean Perrin, we micro-machine micro-channel microstructures for microfluidics and surfaces decorated with pillars and spherical caps for studying mechanotransduction.
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News

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05
NOV 2020

Séminaire/débat 'Monde fini': Allons-nous continuer la recherche scientifique ?'
Le prochain séminaire/débat ‘Recherche dans un monde fini’ aura lieu jeudi 5/11 avec...

17
SEP 2020

Présentation de l'empreinte carbone du LJP
L'empreinte carbone du laboratoire Jean Perrin a été présentée en Assemblée...

11
SEP 2020

PhD defense of Anis Senoussi
I am pleased to invite you to the defense of my thesis which will take place on Friday, September 11th at 2:30...

29
JUN 2020

A basic physical mechanism enables cell migration in absence of adhesion
Many cell types within the organism bind to their environment via specific adhesion molecules (integrins); ...

23
JUN 2020

Thesis defense - Loïc Marrec
I am pleased to invite you (virtually) to my thesis defense which will take place on Tuesday, June 23, 2020 at...

13
FEB 2020

Seminar/debate: Environmental impact of the digital world
La prochaine séance du groupe de réflexion "Faire de la recherche dans un monde fini" sera ...

Latest publications

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⊞	Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment - Genetics
	L. Marrec , A.F. Bitbol

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Bibtex

doi:10.1534/genetics.120.303624

⊞	Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures - Nat. Cell Biol.
	S. Massou , F.N. Vicente , F. Wetzel , A. Mehidi , D. Strehle , C. Leduc , R. Voituriez , O. Rossier , P. Nassoy , G. Giannone

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doi:10.1038/s41556-020-0548-2

⊞	Blind deconvolution for spike inference from fluorescence recordings. - Journal of Neuroscience Methods
	J. Tubiana, , S. Wolf, , T. Panier , G. Debrégeas

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doi:10.1016/j.jneumeth.2020.108763

⊞	Collective stiffening of soft hair assemblies - Physical Review E Rapid Communication
	J.B. Thomazo, , E. Lauga, , B. Le Révérend, , E. Wandersman , A.M. Prevost

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doi:10.1103/PhysRevE.102.010602

⊞	Collective Dynamics of Focal Adhesions Regulate Direction of Cell Motion - Cell Syst.
	S. Lo Vecchio , R. Thiagarajan , D. Caballero , V. Vigon , L. Navoret , R. Voituriez , D. Riveline

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Bibtex

doi:10.1016/j.cels.2020.05.005