Home  >  People  >  Frédéric Joubert
Frédéric Joubert frederic.joubert@upmc.fr
CNRS Research scientist ORCID 0000-0003-0239-1052
Office (room 418)
Fax
(+33) 1 44 27 90 64
(+33) 1 44 27 47 16

Research interests

Biomembrane plasticity and cellular function

Presentation

After 15 years spent in physiology laboratories studying cardiac energetic and mitochondria functioning, I decided to join Jean Perrin laboratory at UPMC. Using biomimetic systems such as lipid vesicles (GUVs), I study the properties of mitochondrial lipids, and in particular cardiolipids. I also try to understand how membrane invaginations mimicking "mitochondrial cristae" can be formed, and how these nanostructures and the resulting compartmentalization can influence the functioning of an enzyme such as the F1Fo ATPsynthase. For this research, I collaborate with various national and international laboratories. My research combines physicochemical and biophysical approaches, but also experiments on culture cells and on animal models having alterations in the organization of their mitochondrial membranes.


Publications

2017

Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F1F0-ATP synthase - Proceedings of the National Academy of Sciences of the United States of America
V.G. Almendro-Vedia , P. Natale , M. Mell , S. Bonneau , F. Monroy , F. Joubert , I. López-Montero
  URL Full text PDF Bibtex doi:10.1073/pnas.1701207114

2014

Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4 - Br. J. Pharmacol.
F. Hubert , M. Belacel-Ouari , B. Manoury , K. Zhai , V. Domergue-Dupont , P. Mateo , F. Joubert , R. Fischmeister , V. Leblais
  URL Full text PDF Bibtex doi:10.1111/bph.12853

2013

Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice - J. Physiol.-London
F. Caffin , A. Prola , J. Piquereau , M. Novotova , D.J. David , A. Garnier , D. Fortin , M.V. Alavi , V. Veksler , R. Ventura-Clapier , F. Joubert
  URL Full text PDF Bibtex doi:10.1113/jphysiol.2013.263079
Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell? - Front. Physiol.
J. Piquereau , F. Caffin , M. Novotova , C. Lemaire , V. Veksler , A. Garnier , R. Ventura-Clapier , F. Joubert
  URL Full text PDF Bibtex doi:10.3389/fphys.2013.00102

2012

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload - Cardiovasc. Res.
J. Piquereau , F. Caffin , M. Novotova , A. Prola , A. Garnier , P. Mateo , D. Fortin , L.H. Huynh , V. Nicolas , M.V. Alavi , C. Brenner , R. Ventura-Clapier , V. Veksler , F. Joubert
  URL Full text PDF Bibtex doi:10.1093/cvr/cvs117
Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin - Am. J. Physiol.-Heart Circul. Physiol.
M. Izem-Meziane , B. Djerdjouri , S. Rimbaud , F. Caffin , D. Fortin , A. Garnier , V. Veksler , F. Joubert , R. Ventura-Clapier
  URL Full text PDF Bibtex doi:10.1152/ajpheart.00467.2011

2011

Bioenergetics of the failing heart - Biochim. Biophys. Acta-Mol. Cell Res.
R. Ventura-Clapier , A. Garnier , V. Veksler , F. Joubert
  URL Full text PDF Bibtex doi:10.1016/j.bbamcr.2010.09.006

2010

Mitochondria as a source of mechanical signals in cardiomyocytes - Cardiovasc. Res.
A. Kaasik , M. Kuum , F. Joubert , J. Wilding , R. Ventura-Clapier , V. Veksler
  URL Full text PDF Bibtex doi:10.1093/cvr/cvq039
Postnatal development of mouse heart: formation of energetic microdomains - J. Physiol.-London
J. Piquereau , M. Novotova , D. Fortin , A. Garnier , R. Ventura-Clapier , V. Veksler , F. Joubert
  URL Full text PDF Bibtex doi:10.1113/jphysiol.2010.189670

2009