Accueil  >  Annuaire  >  Volker Bormuth
Volker Bormuth volker.bormuth@upmc.fr
Maître de conférences UPMC
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01 44 27 20 06
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01 44 27 47 16

Thématiques de recherche

Imagerie calcique et comportement du poisson zèbre

Présentation

 

Multisensory signal processing: From whole-brain activity to behavior

 

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Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherentre presentation of the world. Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and isimplicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensoryprocessing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while thesmallest operational units are single multisensory neurons.

In an interdisciplinary effort, we combine optical developments, genetics and neuro-computation to obtain new insights into the activityof brain-wide neural circuits that process multisensory information. To reduce the complexity, we study the small transparent brain ofzebrafish larvae as a model system. We focus on gaze stabilization as an inherently multisensory model task that is conservedamong all vertebrates. This reflex uses both vestibular and visual information to drive eye movements in order to compensate forself-motion and maintain clear vision. We have developed a novel experimental platform in which a restrained larva can be submittedto vestibular and visual stimuli, as a pilot in a flight simulator. We can optically record the activity of all 100,000 neurons of the animalbrain as it performs multisensory integration tasks.To extract basic principles of how behavior is coded in multisensory neuronal circuits we interpret the brain-wide activity and theobserved behavior with methods from statistical physics. No other system can today provide a similar brain-scale, yet cell-resolvedview on the neuronal network dynamics subserving such a complex integration process.

We use this system to address three fundamental and generic questions relevant to multi-sensory integration.

1 – Multi-sensory enhancement. How multi-modal congruent sensory cues are integrated at the circuit level to enhance the precisionof the evoked motor response?

2 – Decision-making: Resolving conflicting sensory cues. When the brain is submitted to conflicting stimuli, which neuronalmechanism controls the prioritization of one sensory cue over the other?

3 – Cross-modal adaptation. How constantly out-of-register stimuli induces network plasticity in order to recover a coherentrepresentation ?


Publications

2016

2015

Hair-Bundle Friction from Transduction Channels' Gating Forces - MECHANICS OF HEARING: PROTEIN TO PERCEPTION
V. Bormuth , J. Barral , J.F. Joanny , F. Juelicher , P. Martin
  URL Full text PDF Bibtex doi:10.1063/1.4939318

2014

Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear - Proc. Natl. Acad. Sci. U. S. A.
V. Bormuth , J. Barral , J.F. Joanny , F. Juelicher , P. Martin
  URL Full text PDF Bibtex doi:10.1073/pnas.1402556111

2013

Kinesin-8 Is a Low-Force Motor Protein with a Weakly Bound Slip State - Biophys. J.
A. Jannasch , V. Bormuth , M. Storch , J. Howard , E. Schaeffer
  URL Full text PDF Bibtex doi:10.1016/j.bpj.2013.02.040

2012

The Highly Processive Kinesin-8, Kip3, Switches Microtubule Protofilaments with a Bias toward the Left - Biophys. J.
V. Bormuth , B. Nitzsche , F. Ruhnow , A. Mitra , M. Storch , B. Rammner , J. Howard , S. Diez
  URL Full text PDF Bibtex doi:10.1016/j.bpj.2012.05.024

2010

Microtubule Dynamics Reconstituted In Vitro and Imaged by Single-Molecule Fluorescence Microscopy - MICROTUBULES, IN VITRO: MICROTUBULES, IN VITRO
C. Gell , V. Bormuth , G.J. Brouhard , D.N. Cohen , S. Diez , C.T. Friel , J. Helenius , B. Nitzsche , H. Petzold , J. Ribbe , E. Schaeffer , J.H. Stear , A. Trushko , V. Varga , P.O. Widlund , M. Zanic , J. Howard
  URL Full text PDF Bibtex doi:10.1016/S0091-679X(10)95013-9
Studying Kinesin Motors by Optical 3D-Nanometry in Gliding Motility Assays - MICROTUBULES, IN VITRO: MICROTUBULES, IN VITRO
B. Nitzsche , V. Bormuth , C. Braeuer , J. Howard , L. Ionov , J. Kerssemakers , T. Korten , C. Leduc , F. Ruhnow , S. Diez
  URL Full text PDF Bibtex doi:10.1016/S0091-679X(10)95014-0
Breaking of bonds between a kinesin motor and microtubules causes protein friction - OPTICAL TRAPPING AND OPTICAL MICROMANIPULATION VII
V. Bormuth , V. Varga , J. Howard , E. Schaeffer
  URL Full text PDF Bibtex doi:10.1117/12.863545

2009

Kinesin-8 Motors Act Cooperatively to Mediate Length-Dependent Microtubule Depolymerization - Cell
V. Varga , C. Leduc , V. Bormuth , S. Diez , J. Howard
  URL Full text PDF Bibtex doi:10.1016/j.cell.2009.07.032
Protein Friction Limits Diffusive and Directed Movements of Kinesin Motors on Microtubules - Science
V. Bormuth , V. Varga , J. Howard , E. Schaeffer
  URL Full text PDF Bibtex doi:10.1126/science.1174923

2008

Optical trapping of coated microspheres - Opt. Express
V. Bormuth , A. Jannasch , M. Ander , C.M. van Kats , A. van Blaaderen , J. Howard , E. Schaeffer
  URL Full text PDF Bibtex doi:10.1364/OE.16.013831
Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope - J. Neurosci. Methods
Y. Otsu , V. Bormuth , J. Wong , B. Mathieu , G.P. Dugue , A. Feltz , S. Dieudonne
  URL Full text PDF Bibtex doi:10.1016/j.jneumeth.2008.06.015
Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope - J. Neurosci. Methods
Y. Otsu , V. Bormuth , J. Wong , B. Mathieu , G.P. Dugue , A. Feltz , S. Dieudonne
  URL Full text PDF Bibtex doi:10.1016/j.jneumeth.2008.06.015

2007

LED illumination for video-enhanced DIC imaging of single microtubules - J. Microsc.-Oxf.
V. Bormuth , J. Howard , E. Schaeffer
  URL Full text PDF Bibtex doi:

2004

Injection and flow control system for microchannels - Lab Chip
C. Futterer , N. Minc , V. Bormuth , J. Codarbox , P. Laval , J. Rossier , J. Viovy
  URL Full text PDF Bibtex doi:10.1039/B316729A